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Clinical trial data from large cardiovascular outcome studiesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide)have not demonstrated increased fracture risk among patients taking GLP-1 receptor agonists compared with placebo
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Theyre also, in the vast majority of cases, manageable and temporary
The modest effects likely insufficient for substantial weight loss requiring more aggressive approaches
A second follow-up trial was started in the same year and aimed to evaluate the safety of subcutaneous bioresorbable implants of CUV1647 (melanotan I)
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